Glutathione is often called the master antioxidant But it's actually regulated by melatonin (PMID: 20868358) Melatonin has been seen to have 10x the antioxidant capacity than glutathione Besides sleep, melatonin also regulates Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Antioxidant Protection of NADPH Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione Ewa Kilanczyk, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman, 2016 JCI Dual targeting of the thioredoxin and glutathione systems in cancer and HIV